A79B44200000578-121_634x443.jpg' alt='Drug Trials Uk Gone Wrong' title='Drug Trials Uk Gone Wrong' />Invokana Could Be The Worst Diabetes Drug Yet Real Diabetes Truth. Create A Csv File Using Php Includes. Ive said it before beware of new diabetes drugs. And you should be particularly wary of the latest offering from Big Pharma to hit the UK market. Invokana canagliflozin is one of a novel class of drugs called sodium glucose transport protein 2 SGLT2 inhibitors, which work by increasing the amount of glucose passed out of the body in the urine. As the Diabetes UK website blandly puts it Invokana is a relatively new drug and the effects on patients taking the drug for several years are not yet known. Invokana was launched in the UK on 2. February this year and doctors are currently awaiting final guidance from NICE the National Institute for Health and Care Excellence on its recommendations for use on the NHS. These will probably be much the same as draft recommendations on which NICE has already carried out a public consultation. Not that you would have noticed, of course the consultation period was a brief three weeks and only regular visitors to the NICE website would have picked this up. Thousands of candidates may have been affected by the error, which confused the two warring families the Capulets and the Montagues in the famous tragedy Romeo. Whether you are looking for a clinical trial to take part in, information about how trials are planned or for trial results you can find it here. New Anti Aging Drug Trials Truth Serum Collagen Booster New Anti Aging Drug Trials Premature Eye Wrinkles Otc Skin Tag Removal Reviews. Diabetes Drug Help The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. DIABETES DRUG HELP The REAL cause of Diabetes and. Covance%20Clinical%20Trials/Images/CarouselArt/carousel-woman-sitting.png' alt='Drug Trials Uk Gone Wrong' title='Drug Trials Uk Gone Wrong' />Get the latest international news and world events from Asia, Europe, the Middle East, and more. See world news photos and videos at ABCNews. Drug trial that went horribly wrong. On 13 March 2006, six healthy young volunteers took part in a clinical trial and became violently ill minutes after having been. Invokana is a relatively new drug and the effects on patients taking the drug for several years are not yet known. Success stories featuring businesses that have received funding and support from Innovate UK. So, what makes me uneasy about Invokana It seems that this drug is being rushed into use despite a number of safety concerns. E2/production/_88662269_gettyimages-57105406.jpg' alt='Drug Trials Uk Gone Wrong' title='Drug Trials Uk Gone Wrong' />In its consultation document, NICE lists seven shortcomings in the evidence provided by Invokanas manufacturer Janssen, the pharmaceutical arm of Johnson and Johnson, including lack of evidence for longer term efficacy and safety. In other words, they are not sure that this drug really works or whether it is safe for people to take. Despite this, they appear to be happy to give the go ahead for its use and type 2 diabetes patients will be the guinea pigs who will test it. Would you like a genital infection with that Or kidney damage There are plenty of reasons to doubt Invokanas safety. Even the data provided by its makers shows that, because this class of drugs causes glucose to be excreted in the urine, it is associated with a high risk of fungal infections. Fungal pathogens including yeasts such as Candida feed on sugar, so having sugar in your urine is a sure way of promoting their growth. Janssens own data show that a whopping 1. Invokana will suffer a painful and debilitating genital infection as a result of the drug. And you can bet those figures are conservative ones. In addition, clinical trials data show that at least five per cent of users of Invokana are likely to suffer side effects of nasopharyngitis cold like symptoms, hypoglycaemia, upper respiratory tract infection, diarrhoea, joint pain, back pain or headache. Thats five per cent for each side effect, so the total number of people affected will be much higher. More seriously, this drug carries a real risk of kidney damage. Diabetes patients are already at risk of reduced kidney function as a result of their condition, so giving them a drug that increases the chances of this problem just seems crazy. No, on second thoughts, criminal might be a better word. In the USA, the Food and Drug Administration FDA flagged up its concerns that Invokana might also pose a serious risk of cancers, pancreatitis, bone fractures, liver damage, hypersensitivity reactions and adverse pregnancy outcomes before deciding to approve it anyway Giving evidence to the FDAs drug advisory committee, Dr. Sidney Wolfe, director of Public Citizens Health Research Group, warned that the way the drug works, by eliminating glucose in the urine, can cause a cascade of adverse events, including dehydration, which could lead to low blood pressure, dizziness and falls, and damage to the kidneys and heart. It looks as though we shall have to wait several years before Invokanas trail of destruction becomes incontrovertibly clear. By that time, thousands of people with type 2 diabetes could have suffered from its devastating and potentially lethal side effects. And Janssen will have made millions of pounds in profits for its shareholders. The scenario seems set to mirror that of Avandia, the diabetes drug that was in use in the UK for years before being banned in 2. My advice is simple. If your doctor suggests you try Invokana, just say NO. For information on safe herbal alternatives that can equal or exceed the effectiveness of conventional diabetes drugs without the risks of dangerous side effects, see my earlier blog posts here and here. Resveratrol, a polyphenol found in the skins of red grapes, is another natural product that can reduce blood sugar levels and insulin resistance, according to a recent meta analysis of scientific studies. Ill tell you more about this in my next blog post. Wishing you the best of health,Martin Hum. Ph. D DHD Nutritionistfor Real Diabetes Truth Did you find this information useful Sign up now to get instant access to 1. Diet Secrets for Healthy Blood Sugar along with daily updates on how to enjoy good health, naturally. 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